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Notably, the Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) trial, the first dedicated kidney outcome trial evaluating canagliflozin in people with type 2 diabetes mellitus and CKD, demonstrated a substantial reduction in the risk of kidney events [46]

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The molecule was modified with a fatty acid chain that binds to albumin in your blood, protecting it from rapid degradation and allowing it to circulate and activate GLP-1 receptors continuously

Average weight loss reaches 5 to 7 percent of baseline by week 8