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Most studies remain early-phase investigations, and many unanswered questions persist regarding dosing, patient selection, duration of therapy, and long-term neurological outcomes

These treatments are not appropriate for all patients and may be contraindicated in individuals with certain medical conditions including hormone-sensitive cancers, blood clotting disorders, severe liver disease, or cardiovascular conditions

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These studies provide a detailed picture of its dose-response relationship and performance over extended periods

This is particularly important when switching from a GLP-1 based therapy to non-GLP-1 options, because the metabolic adjustment can affect blood sugar regulation, blood pressure, and heart rate in ways that warrant monitoring