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Interestingly, chronic chemo-genetic stimulation of POA LepR-expressing neurons decreases both food intake and energy expenditure, and results in body weight loss, indicating that the reduced food intake surpasses the decreased energy expenditure [28]

J Nutr (1980) 110(5):88390

CT with oral and IV contrast or MRI imaging of the esophagus are the most useful diagnostic modalities

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molecular instability can produce inconsistent results that invalidate research protocols or create unpredictable physiological responses

The system's ability to maintain weight at a higher setpoint is disrupted from three directions at once