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Less Common but Serious Side Effects Some less common but more serious GLP-1 side effects are worth being aware of: Pancreatitis (inflammation of the pancreas) Gallbladder problems (including gallstones) Acute kidney injury (usually as a result of severe dehydration from vomiting or diarrhea) Diabetic retinopathy worsening (particularly in patients with rapid improvement in blood sugar control) Hypoglycemia (when combined with other diabetes medications like sulfonylureas or insulin) All GLP-1 medications also carry a warning regarding a theoretical risk of medullary thyroid carcinoma, based on animal studies

By the 1980s, the amino acid and gene sequences of proglucagon (Figure 1) were unraveled

The fatty tissue in your upper armspecifically the outer portionprovides a safe subcutaneous layer for drug absorption without hitting muscle or bone

Lancet (2016) 387:67990

NICE guidance recommends these as first-line options for patients with established cardiovascular disease, heart failure or chronic kidney disease

The effectiveness of lifestyle interventions in heart failure with preserved ejection fraction: a systematic review and network meta-analysis
