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Type 2 Diabetes (Oral Therapy)# Recommendation : Orforglipron Reason : ACHIEVE-3 directly demonstrated orforglipron 36 mg superiority over oral semaglutide 14 mg for HbA1c reduction (2.2% vs 1.4%) and weight loss (9.2% vs 5.3%) in type 2 diabetes
The training provides the stimulus
46 GLP-1(9-36) (amide) reduced elevated levels of mitochondrial-derived ROS in the hippocampus of AD model (APP/PS1) mice
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Due to the way the medication works, weight tends to come back when you stop using it
The risk of CV mortality increases with increased CKD staging, regardless of diabetes status
