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Contributor Information Stina Brchers, Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, 41390 Gothenburg, Sweden

They are used to regulate appetite and blood sugar levels

Well-known drugs like semaglutide (Ozempic and Wegovy ) act on this pathway

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And real-world patients, the ones living with this medication day to day, sometimes describe mood changes that clinical trial data alone cannot explain

In preclinical models of alcohol use disorder (AUD), central GLP-1R activation in reward-related regions such as the VTA and NAc attenuates ethanol intake, conditioned place preference, and stress-induced reinstatement of alcohol-seeking behavior [7]