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[15] [18] Patients should maintain adequate hydration when using both medications and should avoid taking ibuprofen if experiencing significant vomiting or diarrhoea until properly rehydrated

These natural agents do not act as pharmaceutical GLP-1 drugs, but may support similar metabolic pathways, helping regulate appetite, blood sugar, and weight, says Butner

Together, they offer a holistic approach to weight management and overall health

However, none of the study participants had markedly increased ( 3 times the upper limit of normal range) pancreatic amylase levels in either the tirzepatide (all doses) or the GLP1RA group in another study, NCT03131687 [13, 25]

In the semaglutide obesity study, 4.5% of participants in the treatment arm discontinued treatment due to gastrointestinal events