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Based on the earlier discussed receptor expression, innervation and their crucial role in behavioral control two mesolimbic nuclei, the VTA and the NAc, became the first targets of studies exploring behavioral consequences of the mesolimbic GLP-1R activation

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Activation of GLP-1R slows gastric emptying, enhances glucose-dependent insulin secretion from pancreatic beta cells, suppresses inappropriate glucagon secretion, and produces a robust central satiety signal via vagal afferents and hypothalamic circuits