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The magnitude of the benefits of GLP-1RA and SGLT-2 inhibitors on MACE are similar in patients with T2D, ranging from 12 to 14% reduction of risk, but only GLP-1RA may reduce the risk of stroke (Fig

10.1136/bmjdrc-2022-003206 13 D'AlessioD.HringH.CharbonnelB.de PablosVelascoP.CandelasC.DainM.et al (2015)

Lack of Lifestyle Support & Side Effects Driving Dropout Poor long-term adherence is not the patients fault its a predictable outcome when medications are prescribed in isolation

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Supporting this hypothesis, we demonstrate that GLP-1 receptor-mediated targeting of MK-801 effectively avoids other adverse effects associated with MK-801 monotherapy, including hyperthermia and hyperlocomotion
