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Metabolic Adaptation (Adaptive Thermogenesis) Beyond body size alone, the body also responds to weight loss by becoming more energy-efficient a phenomenon called adaptive thermogenesis

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Mild to moderate nausea is common when starting this medication and often improves with time

So, in effect, the GLP-1s replace a hormone that gets low when people try to lose weight, thus allowing for sustained weight loss without the person feeling hungry all the time

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It produces hormones, cytokines, and other signaling molecules that affect brain function