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What is the hormone GLP-1, what separates GLP-1 mimics from previous weight-loss drugs, and how much weight may be lost before weight loss plateaus?

Chronic knockdown of LH GLP-1R induced by intraparenchymal delivery of an adeno-associated virus-short hairpin RNA construct was sufficient to markedly and persistently elevate ingestive behavior and body weight and ultimately resulted in a doubling of fat mass in males and females

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