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Once it reaches the bloodstream, it is directly inactivated within seconds by the enzyme dipeptidyl peptidase-4 (DPP-4), which cleaves the peptide between positions 8 and 9, converting it into the truncated form GLP-1(936) amide

Larger-scale federally licensed compounders (503B outsourcing facilities) have until March 19, 2025, to wind down their production and distribution of compounded tirzepatide

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