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In people with obesity and established cardiovascular disease but without diabetes, semaglutide 2.4 mg resulted in 20% reduction in major adverse cardiovascular events [(MACE), death from cardiovascular causes, nonfatal myocardial infarction or nonfatal stroke] compared to placebo (SELECT trial) after a mean follow-up of 39.8 months this is the first trial demonstrating cardiovascular benefit for an obesity pharmacotherapy [110]

these risks exist across all doses and are monitored during treatment

This latest investigation aimed to determine the effects of semaglutide on both health profiles and health care utilisation across a diverse adult population

Additionally, Semaglutide reduces oxidative stress by decreasing the production of reactive oxygen species (ROS) and increasing the activity of antioxidant enzymes

Mild reactions may allow continuation under a doctor's supervision