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Discuss severe, persistent, or worsening symptoms with your provider

In higher doses of 50 mg (which may be prescribed off-label), the average weight loss is 15.1% in 68 weeks, according to a separate study

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4,5 Clinical outcomes Across phase II data for the once-daily, non-peptide GLP-1R agonist orforglipron in obese adults without diabetes, mean weight loss of 9.414.7% 6 was reported by week 36, depending on the dose, as compared to 2.3% with placebo