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48 As an add-on to insulin with or without metformin (PIONEER 8), oral semaglutide (at doses of 3, 7 and 14 mg) was shown to be associated with superior HbA1c and body weight reductions versus placebo as early as at week 26 and achieved further reduction in insulin need (except dose 3 mg) at week 52, without significantly increasing the rate of hypoglycemia

In the Redox Biology study described earlier [5], individuals with type 2 diabetes treated with GLP-1 receptor agonists demonstrated reduced ROS production, restoration of mitochondrial membrane potential, improved oxygen consumption, and lower levels of myeloperoxidase (MPO)

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Retrieved from: Karagiannis et al., 2023

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Researchers administered a daily intraperitoneal dose of exenatide (5 nmol/kg body weight) to 11-month-old mice , continuing the treatment for 30 weeks [10]