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In addition to the direct impact on the proportion of gut bacteria, GLP-1RAs were found to upregulate tight junction proteins in the intestinal mucosa, which helps prevent the translocation of bacteria to the blood

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Most common side effects from these medications occur primarily along the digestive tract and include: Nausea Bloating Vomiting Diarrhea Indigestion Belching Flatulence Much of the digestive discomfort people experience comes from slowed gastric emptying, which is another way of saying that youll digest food more slowly

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Diabetes 56 , 815 (2007)