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However, Glp1r/ mice treated with the GLP-1/Gcg coagonist experienced a reduction in body weight and fat mass but did not have improvements in glucose tolerance indicating that GLP-1R agonism is required to counteract the hyperglycemic effects of GcgR agonism (Day et al., 2009)

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Although the drugs can effectively reduce weight and improve some metabolic indicators, they are often accompanied by a decrease in fat-free mass, and this contradiction mainly arises from the inherent differences in research models, physiological backgrounds, and intervention conditions

However, many patients prefer injecting after a small meal because it helps them avoid nausea in the minutes following the shot