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It is possible to stay on a lower dose for an extended time if needed to mitigate side effects

Please note that energy requirements vary significantly based on age, sex, weight, activity level and medical conditions

Taking more than directed may cause serious liver injury

Semaglutide's Effects on Kidney Function and Hydration Status Semaglutide reduces appetite and increases feelings of fullness, which means patients naturally consume less food and sometimes less fluid

Patients with a history of hypertension, cardiac arrhythmias, or hyperthyroidism face additional risks that make this combination particularly problematic

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