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Some practitioners theorize that establishing robust GLP-1-supporting gut bacteria before discontinuing medication could provide a partial buffer against rebound effects, maintaining some degree of natural GLP-1 production even after the pharmaceutical support is removed

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Health coaches should be aware of this distinction when discussing semaglutide with clients

While phentermine is approved by the FDA for short-term use, many healthcare providers will prescribe it off-label for longer periods of time (or intermittently, with some time on and some time off)

Derek Lowe