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That's why fitter individuals show smaller increases in HR

In subgroup analysis, lower AF risk was seen in GLP-1RA versus DPP4i users who achieved weight loss, which suggests weight loss as a potential modifier of response to GLP-1RAs.

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Understanding this process more clearly could help researchers design the next generation of GLP-1-based treatments that are even more precise and effective, first author Sam Van de Velde told BioWorld.