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Tirzepatide has shown a slightly higher rate of acute gallbladder disease (0.6% versus essentially zero in placebo groups), which can secondarily affect liver function through biliary obstruction

Can J Diabetes (2014) 38(5):36471.10.1016/j.jcjd.2014.05.001 67 KrasnerNMIdoYRudermanNBCacicedoJM

The drugs multifaceted impact on metabolism, body fat, and general well-being makes it a compelling choice for those who require more than lifestyle interventions

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Their rational combination represents a promising direction in engineering next-generation GLP-1R-targeted therapeutics