exenatide glp 1 agonist GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus Further support for GLP-1R agonists

doi: 10.1007/s10334-019-00773-z

( 10.1042/BSR20181767) [DOI] [PMC free article] [PubMed] [Google Scholar] Lincoff AM, Brown-Frandsen K, Colhoun HM, Deanfield J, Emerson SS, Esbjerg S, Hardt-Lindberg S, Hovingh GK, Kahn SE, Kushner RF, et al

Similarly, semaglutide decreased plaque progression in LDLR-deficient mice by downregulating pro-inflammatory chemokines [24]

(1) (2) This peptide mimics GLP-1 but lasts much longer in the body, making it a valuable blueprint for modern medications

The excessive intake of sugary beverages, fast food, and snacks is directly connected to weight gain and impaired glucose metabolism

This work has been widely read as evidence that neuroinflammation is a driver of neurodegeneration rather than merely a downstream marker, although that interpretation remains the subject of active investigation