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5456 GLP-1 treatment also leads to reduced phosphorylation and nuclear translocation of nuclear factor-B (NF-B) in mouse intestinal macrophages (Figure 2B)

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At the same time, type 1 diabetes is experiencing an unexplained epidemic, with its prevalence steadily rising since the 2010s

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The landmark SELECT trial demonstrated that semaglutide reduces major adverse cardiovascular events in patients with overweight or obesity without diabetes, supporting expanded use of GLP-1RAs beyond glycemic control

These events were predominantly mild to moderate in severity and occurred most frequently during the dose-escalation period