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In participants with baseline BMI 35 who continued on 12 mg through 104 weeks of total treatment: average weight loss of 85.0 lb (30.3%)

However, tirzepatide monotherapy carries a low intrinsic risk of hypoglycaemia due to its glucose-dependent mechanism of action

(18) Concomitant use of medications that cause weight gain or weight loss

GLP-1 RAs exert direct and indirect effects on the CV system including vasodilation, natriuresis anti-atherosclerotic effects, improvements in endothelial function, anti-inflammatory effects (decrease cytokines level such as tumor necrosis factor, interlukin-1, interlukin-6) and a consequent decrease in C-reactive protein, and reductions in infarct size ( Figure 2 Recently, GLP-1 RAs have been recommended by different guidelines

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