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Semaglutide compound reference available on PubChem

Nausea (25-60%), vomiting, diarrhea, and constipation are most frequent

An endogenous GLP-1 circuit engages VTA GABA neurons to regulate mesolimbic dopamine neurons and attenuate cocaine seeking (2025)

The key distinction is adherence: patients who experience manageable nausea and stick with their treatment tend to see better results than those who stop taking semaglutide due to side effects

Bagsvaerd, Denmark: Novo Nordisk