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Moreover, downregulation of GLP-1R level is also found in the glomerular endothelial cells of diabetic mice, which may be due to increased GLP-1R degradation resulted from diabetes-induced PKC2 activation 28

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* For those taking Wegovy pill, 76% achieved 5% or greater body weight loss (from a baseline body weight of 235 lb) versus 31% taking placebo (from a baseline body weight of 231 lb)

The authors found no significant difference in the risk of NAION among new semaglutide users when compared to users of other GLP-1 RAs or non-GLP-1 RAs therapies, except empagliflozin [93]

Collectively, these mechanisms optimize cardiac energy metabolism, mitigate oxidative stress, and support overall cardioprotection