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Description
The STEP 1 trial recorded that 86% of participants had lost at least 5% of their body weight by this point, and over 50% had lost 10% or more
By complementing monoaminergic mechanisms with modulation of reward-related pathways and inflammatory tone, GLP-1 RAs may work synergistically with conventional antidepressants, particularly in subtypes characterized by anhedonia or treatment resistance [63,66]
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