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Some patients transition to lower doses or less frequent administration to balance cost and side effects with weight maintenance
doi: 10.1038/ejcn.2009.55

Conclusion: First line use of SGLT2i and GLP-1RAs is effective in reducing HbA1c, weight, and FPG levels in T2DM patients at low risk for cardiovascular disease

2023 NEJM), which showed 20% reduction in major adverse cardiovascular events over 39-month mean follow-up in patients with established CVD and BMI 27+
HR 0.86
doi: 10.1056/NEJMoa1504720 36 HolstJJ
