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Unfortunately, they are not very potent since they have a short half-life in vivo
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These effects persist for 24 to 72 hours following a single bout of moderate-intensity aerobic exercise (Colberg et al., 2016
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If staying at very low doses long-term worked as well, RCTs would reflect that by now
Therefore, one possible mechanism for the GI intolerance associated with metformin may relate to altered transport of serotonin or to a direct serotonergic-like effect of metformin
