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The is 2013 - 2016: It all started with Novartis developing Bimagrumab and receiving an FDA breakthrough designation in August 2013 for sporadic inclusion body myositis.In 2016, it failed a Phase IIb/III trial

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This shift from "Large Molecule/Biologic" to "Small Molecule/Chemical" changes everything: Easier Synthesis: They are produced via standard chemical synthesis rather than complex biological fermentation or solid-phase peptide synthesis (SPPS)