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Clarification of a number of important, unresolved concepts will be dependent on the outcomes of future targeted research

Safety Profile and Side Effects Reported in the Trial The most common adverse effects were gastrointestinal particularly nausea, vomiting, and diarrhoea occurring most frequently during dose escalation and generally mild to moderate in severity

Retatrutide (12 mg) is an investigational, long-acting synthetic peptide originally developed by Eli Lilly and evaluated in Phase 2 and ongoing Phase 3 clinical research

Glucagon increases energy expenditure through brown adipose tissue activation and other thermogenic mechanisms

These gastrointestinal issues make sense when we consider that two of the main GLP-1RA actions are slowing gastric emptying (digestion) and altering appetite signals (discussed in Part 1)

However, APS patients are often on anticoagulation therapy, and tirzepatide delayed gastric emptying could theoretically affect oral anticoagulant absorption