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President Donald Trump has signed a sweeping executive order setting a 30-day deadline for drugmakers to lower the cost of prescription drugs in the U.S.

However, no retrospective epidemiological studies can provide definitive answers, and nausea, vomiting and diarrhoea remain the most clinically relevant adverse effects of these drugs, compromising long-term adherence.

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For GLP-1 users, those outcomes are not theoretical, they map directly onto daily challenges around energy dips, under-eating and nutritional adequacy.