glp 1 drugs history Reflections on the discovery GLP-1 as a satiety hormone: Implications for obesity therapy and future directions The expanding landscape of GLP-1
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Treatment with exenatide increased insulin signaling pathway activity, AMPK signaling pathway activation, and lipid oxidation enzyme stimulation [73]
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In addition to the different study populations and study design in these trials, one potential reason for this heterogeneity in cardiovascular benefit is the structural differences among the GLP-1RAs used in these trials
Furthermore, fluctuations in blood sugar levels, particularly hypoglycemia, can lead to sensations of tiredness
There is also a concern about long term effects, so people with a history of pancreatitis, for example, would be unlikely to be prescribed a GLP-1
