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Currently approved injectable GLP-1 treatments (semaglutide and liraglutide) have established efficacy and safety profiles with proven weight loss outcomes in clinical trials

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Of note, in addition to glucagon, the pancreas contained a large peptide with immunoreactive determinants for both GLP-1 and GLP-2 (but not glucagon), consistent with incompletely cleaved proglucagon (major proglucagon fragment [MPGF]) (Figure 3, A and C, and ref
