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Given the lack of individual preclinical models of PCOS that recapitulate all the metabolic, endocrine, and gonadal traits of the clinical syndrome, pharmacological testing was conducted in parallel in these two PCOS models, which are among the most reliable to mimic the metabolic and gonadal phenotype of women with PCOS 36,37 , capturing also the heterogeneity of this condition 38

Moreover, TZT increases anti-inflammatory adiponectin and IGF (Thomas et al

This anti-inflammatory effect may partially counterbalance catabolic stimuli, though lean mass loss remains a concern

Surging demand for these drugs has transformed pharmaceutical giants Novo Nordisk and Eli Lilly $LLY into some of the worlds most valuable companies potentially paving the way for the first $1 trillion pharma firms

Clin Ther

Due to this, Mounjaro is often called a dual action treatment