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Instead, binding of leptin to LepRb initiates a signaling cascade beginning with activation of the tyrosine kinase of the Jak kinase family (JAK2) [84, 85]

This initial phase is driven by reduced calorie intake due to decreased hunger, not fat loss or metabolic changes

GLP-1 medications work by directly activating hormone receptors that regulate appetite and blood sugar

Effective management involves optimising nutrition despite reduced appetite, maintaining hydration, addressing gastrointestinal symptoms, and implementing lifestyle modifications to support energy levels

However, sermorelin requires multiple injections weekly and works gradually over several months before noticeable weight loss occurs

Circulation 2020;141(16):12951306