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The precise contribution of GIP receptor activation to weight reduction remains an area of active study

Glucagon: Encourages the body to pull energy from stored fat

Repeated rubbing of irritated eyes weakens collagen and contributes to both puffiness and pigmentation over time
Proceedings of the National Academy of Sciences of the United States of America , doi:10.1073/pnas.1513004112 (2015)

Whether that tradeoff-lower cost in exchange for a product that hasn't gone through FDA approval as a finished product-is acceptable depends on your individual values, risk tolerance, and circumstances

For others, it may persist, requiring ongoing management