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Oxidative stress with an activation of the renin-angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction

However, more evidence is needed

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Increased colonic expression of Isnl5 is also observed in germ-free (GF) mice, which lack a gut microbiome (168) and microbial-produced colonic short-chain fatty acids (SCFAs)

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