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The observations in SUSTAIN-6 are predictable, given that intensified versus conventional insulin therapy is well known to have the capacity to precipitate initial worsening of retinopathy in patients with T2D with advanced preexisting retinopathy, as shown in the Diabetes Control and Complications Trial (82)
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With no current drug-based treatments available, this trialpersonally funded by Dr
However, a recent study showed that 24.5% IBS-D patients presented with a higher level of total BAs and Clostridia bacteria (Zhao et al., 2020)
