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Diabetes Spectrum : A Publication of the American Diabetes Association

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Notably, STZ-treated animals exhibit alterations in mitochondrial dynamics, including increased expression of fission proteins such as Drp1 and Fis1, accompanied by decreased levels of fusion-related proteins like Mfn2 and OPA1, particularly in the hippocampus and in the prefrontal cortex (Paidi et al., 2015