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The general recommendation for a sample size to assess the safety of a weight-reduction drug is 3,000 subjects randomized to the investigational drug within the to-be258 recommended dosage range and no fewer than 1,500 subjects randomized to placebo for at least 1 year of treatment at the maintenance dosage Multiple #obesitytrials have successfully used flexible dosing regimens

ATTAIN-1 Trial Highlights: - Mean weight loss of ~12.4% over 72 weeks for patients on the highest dose - Participants lost an average of 25 pounds (11.1%) regardless of trial completion - Safety profile consistent with GLP-1 class

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"I feel better not only physically, but mentally." Learn how the GLP-1 treatment changed Laura's life