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PIONEER 9 was a 52-week, phase 2/3a, randomized, controlled trial to assess the efficacy, dose response, and safety of oral semaglutide monotherapy (3, 7, or 14 mg) compared with placebo and liraglutide 0.9 mg in 243 Japanese patients with type 2 diabetes uncontrolled on diet and exercise or one oral glucose-lowering drug (washed out during run-in) [52]

The medication also has contraindications for those with known hypersensitivity to tirzepatide or its excipients

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