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24 With respect to linking reward to hedonic experience, recent evidence points to an important role for the orbitofrontal cortex (OFC), an area that receives converging sensory input

We have further shown that this effect could originate from the hypothalamus, as a dual agonist of GLP-1RA with GIP had a synergetic effect in decreasing feeding behavior compared to GLP-1 or GIP alone when delivered to the hypothalamus in an ICV manner [83]

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doi: 10.1038/modpathol.2014.113 83 HegedsLShermanSITuttleRMvon ScholtenBJRasmussenSKarsblJDet al

Science 369 , eaba3066 (2020)
