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Physical Activity is strongly associated with sustained weight loss maintenance

It is the difference between a medication that works as intended and one that has quietly lost potency while sitting in your bathroom cabinet

Circulation 2020;142:2205-15.ArticlePubMedPMC 92

Promotes metabolic effects: It improves insulin response and glucose control, which contributes to better metabolic health and supports sustained weight loss

The UK product information includes a warning (though not a formal contraindication) for patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, advising vigilance for symptoms such as neck lumps or hoarseness