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Background: The evidence on berberine stimulating the secretion of GLP-1 in intestinal L cell has been studied

As the popularity of GLP-1 drugs continues to skyrocket, there has also been a huge rise in overdoses

The magnitude of the benefits of GLP-1RA and SGLT-2 inhibitors on MACE are similar, ranging from 12 to 14% reduction of risk, but only GLP-1RA may reduce the risk of stroke

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### Competing Interest Statement ASK, AMM, MCG, JMD, CB, CL, SWB, DJL, PML, DRD, JMC, JPF, YL, ARS, DAT, DWP, SH, RBR, MSL, and DAG are employees and stockholders of Pfizer Inc

Obesity management: Used widely for weight loss, even in non-diabetic individuals