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This stigmatization affects clinical decision-making, as practitioners may view obesity as a behavioral issue rather than a chronic disease requiring prompt pharmacological intervention

Without a structured maintenance plan, most patients regain 5070% of lost weight within 12 months of stopping

2021;42 doi: 10.1016/j.eclinm.2021.101213

Their mechanism of action involves several complementary pathways: Enhancing glucose-dependent insulin secretion from pancreatic beta cells, which helps lower blood glucose levels when they are elevated Suppressing glucagon release from pancreatic alpha cells, reducing hepatic glucose production Slowing gastric emptying , which moderates the rate at which nutrients enter the bloodstream Promoting satiety through central nervous system effects, leading to reduced appetite and caloric intake These combined effects result in improved glycaemic control in people with type 2 diabetes and significant weight loss in those using higher doses for obesity management

Weight loss plays a crucial role in improving fertility for women with PCOS

& Devarajan, P