do glp 1 drugs cause muscle loss GLP-1 and Loss: Semaglutide, Tirzepatide & Lean Mass GLP-1s don’t inherently cause muscle

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(2021) Glutamine deprivation triggers NAGK-dependent hexosamine salvage Anthony A

10.1016/j.mce.2015.02.017 17 SodhiM.RezaeianzadehR.KezouhA.EtminanM

10.1016/j.pnpbp.2010.12.017 [DOI] [PubMed] [Google Scholar] Mainardi M., Fusco S., Grassi C

The initial product GLP-1 (137) is susceptible to amidation and proteolytic cleavage, which gives rise to the two truncated and equipotent biologically active forms, GLP-1 (736) amide and GLP-1 (737)

Moving from insulin to GLP-1 A patient on basal insulin whose Type 2 diabetes is relatively well controlled might transition to a GLP-1 agonist if they are gaining excessive weight on insulin, want to simplify their regimen, have developed cardiovascular risk factors that would benefit from GLP-1 protection, or have adequate remaining beta cell function