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GLP-1 is mainly produced in the enteroendocrine L cells located in the distal intestine exerting its effects through binding to the GLP-1 receptors (GLP-1R) expressed in the pancreas, heart, blood vessels, gastrointestinal tract (GIT), kidney, lung, breast, and central nervous system [11],[12]

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Genetic variants in genes like FTO (rs9939609) and MC4R (rs17782313) influence baseline appetite regulation and weight-loss potential, helping clinicians tailor medication selection and dosing strategies