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Interestingly, kinome analysis of mouse islets demonstrated that an acute treatment with exendin 4 increased pRb phosphorylation and subsequent E2f1 transcriptional activity

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To determine the changes in microglial activation, IL-1 and TNF- were examined by western blotting, and the number and morphology of microglia were measured by immunofluorescence

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Results are less dramatic than injectable medications, but a manufacturer has signalled intent to apply for approval in the US.