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NICE guidance emphasises individualised glycaemic targets, particularly when multiple medications affecting glucose metabolism are used concurrently
This approach reflects the success seen with SGLT2 inhibitors, which have demonstrated significant cardioprotective and anti-inflammatory effects in conditions such as SLE, leading to their integration into clinical practice for autoimmune diseases ( Statements Author contributions GC: Conceptualization, Data curation, Investigation, Methodology, Writing original draft, Writing review & editing

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In addition to reducing the cholesterol content of plaque, lipid lowering reduces the accumulation of macrophages, which produce proteolytic enzymes, such as matrix metalloproteinases (MMPs, especially MMP-1, MMP-2, MMP-3, MMP-9, and MMP-13) [13]

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